Endocrine Abstracts

Dehydroepiandrosterone (DHEA) and its sulfated ester (DHEAS) are the most abundant circulating steroid hormones. Their physiological function has yet to be determined. Hypoadrenal subjects lack this hormone because DHEA replacement is not part of the current standard of care. There are conflicting reports on the impact of DHEA replacement in hypoadrenal subjects on insulin sensitivity.We aimed to test this hypothesis and examine skeletal muscle physiolog...

Glucokinase (GCK) serves as the blood glucose ‘sensor’ in pancreatic β-cells, being critically involved in transducing elevated blood glucose into increased insulin secretion. Inactivating GCK mutations cause a subtype of maturity onset diabetes of the young (MODY), whereas activating mutations are a rare cause of hyperinsulinaemic hypoglycaemia, usually presenting in infancy.We now describe the case of a 60-year-old woman who first presen...